This article discusses the importance of introducing educational programs for preschool children to master basic knowledge of science, technology, engineering and mathematics (STEM knowledge). It is proven that teaching STEM knowledge to pre-school children gives them great potential for further development in primary and secondary school. When revealing the subject of STEM knowledge for preschoolers and the gender aspects of its successful teaching, it is concluded that, along with the preparation of such educational programs, it is necessary to develop the special knowledge of boys and girls.